International Journal of Chinese Medicine
Volume 1, Issue 1, January 2017, Pages: 1-9

A Review of Composition and Health Effects of Lycium barbarum

Emine Kocyigit, Nevin Sanlier*

Faculty of Health Sciences, Nutrition and Dietetic Department, Ankara, Turkey

Email address:

(N. Sanlier)
(E. Kocyigit)

*Corresponding author

To cite this article:

Emine Kocyigit, Nevin Sanlier. A Review of Composition and Health Effects of Lycium barbarum. International Journal of Chinese Medicine. Vol. 1, No. 1, 2017, pp. 1-9. doi: 10.11648/j.ijcm.20170101.11

Received: December 24, 2016; Accepted: January 5, 2017; Published: January 24, 2017

Abstract: Lycium barbarum has a radical place in traditional Chinese medicine, also draws attention due to the potential health benefits in recent years. The antioxidant effects of Lycium barbarum have been studied in many aspects: as an anti-aging agent, for general health protection, against tumor growth, for the development of the immune system regulatory, to develop vision, and to protect against cancer and diabetes. High amounts of polysaccharide and carotenoid content are the main components of the antioxidant activity. The structure also contains a high percentage of B group vitamins, such as B1, B2, B6, and minerals, such as Fe, Zn, and Cu. Although it is natively grown in China and other Asian countries, it’s also cultivated in the Mediterranean countries, North America, and Australia. In this study, the components of Lycium barbarum, their properties, and its positive and negative effects on human health are presented.

Keywords: Lycium barbarum, Lycium barbarum Polysaccharide, Nutrition, Health Effect

1. Introduction

Lycium barbarum, a type of berry fruits, belongs to Solanaceae plant family and it is a functional food [1-3]. Lycium barbarum has been widely used as plant and supplement for more than 2000 years in traditional Chinese medicine, and it has been widely cultivated in China, Tibet, and other Asian countries. It is also known as Fruktus Iycii, Gougizi, and Goji berry in China [4]. Lycium barbarum, recently known as "wolfberry" in Europe and North America, has been gaining popularity thanks to its vitamin-mineral content (Group B vitamins such as B1, B2, B6, vitamin C, Fe, Zn, Cu etc.) and its high nutritional value. Today Lycium barbarum is planted primarily in the Mediterranean countries, as well as in North America and Australia [5].

Lycium barbarum is generally dried and then consumed. When dried, it looks like raisin. It is added to tea, alcoholic beverages, soups, yoghurt, vegetable and meat dishes, rice gruel, and porridge. There is a substantial demand for its juice and jelly in many countries because of its consumption is convenient in these forms. Its harvest period begins in August and lasts till October [2]. The size of Lycium barbarum fruits is about 1-2 cm and its color is bright orange-red [3]. Taste and ripening of this fruit are determined by the sugar and organic acids in it. Sugar and organic acids are also important factors in determining the organoleptic properties of the fruit [6]. This fruit has been used for its curative properties in Chinese medicine for more than 2300 years [7]. Lycium barbarum is very beneficial for human body with its many positive effects, such as anti-aging, preventing tumor development, regulating immune system, improving visual sense, and protecting against cancer [8]. Researchers have found records of ancient botanists stating that Lycium barbarum heals kidneys and increase the luster in eyes, and they have also highlighted that antioxidant activity is the source of these protective effects [8,9]. Besides its vitamin and mineral content, Lycium barbarum is the focus of attention with its polysaccharide, betaine, lutein, and zeaxanthin content [9].

2. Composition of Lycium barbarum

Authorities define Lycium barbarum as an exotic super food due to its high amount of polysaccharide, vitamin, and carotenoid content [2]. Energy and nutrient content of edible fresh and dried Lycium barbarum fruit is given in Table 1.

Table 1. Energy and nutrients content of edible fresh and dried Lycium barbarum fruit (100 g) [2,10].

Energy and nutrients content Dried Fresh
Energy (kcal) 349 -
Protein (g) 14.26 4.49
Fat (g) 0.39 2.33
Carbohydrate (g) 77.06 9.12
Pulp (g) 13.0 -
Ca (mg) 190 -
Fe (mg) 6.8 -
Na (mg) 298 -
Vitamin C (mg) 48.4 -
Vitamin A (IU) 26822 -
Thiamin (mg) - 0.23
Riboflavin (mg) - 0.33
Niacin (mg) - 1.7

2.1. Polysaccharides

Approximately 5%-8% of the dry weight of Lycium barbarum consists of Lycium barbarum polysaccharides or glycoconjugates (LBP) [8]. Besides acidic heteropolysaccharide, polypeptide or protein including complex glycoproteins, it is also known to contain high amount of xylose and glucose, and low amounts of arabinose, rhamnose, mannose, and galactose. LBP also includes galacturonic acid and 18 amino acids. Furthermore, Lycium barbarum fruit also includes scopoletin (6-methoxy-7-hydroxycoumarin, also named chrysatropic acid, ecopoletin, gelseminic acid, and scopoletol), vitamin C analog 2-O-β-D-glucopyranosyl-L-ascorbic acid, carotenoids (zeaxanthin and β-carotene), betaine, cerebroside, β-sitosterol, flavonoids, amino acids, minerals, and vitamins (in particular, riboflavin, thiamin, and ascorbic acid) [4,11]. Polysaccharides in Lycium barbarum are summarized in Table 2.

Table 2. Polysaccharide Components Isolated from Lycium barbarum [14].

Glycoconjugates Carbohydrate Content (%) Monosaccharides
LbGp2 90.71 Arabinose, galactose
LbGp3 93.6 Arabinose, galactose
LbGp4 85.6 Arabinose, galactose,
Rhamnose, glucose
LbGp5 8.6 Rhamnose, arabinose,
Xylose, galactose, mannose,
LbG5B   Rhamnose, arabinose,
Glucose, galactose,
Galactose (u)
LBP1a-1   Glucose
LBP1a-2   Glucose
LBP3a-1   GalactoseA
LBP3a-2   GalactoseA
LBP3p 92.4 Galactose, glucose,
Rhamnose, arabinose,
Mannose, xylose
LBPA1   Heteroglycan
LBPA3   Arabinose, galactose
LBPB1   Arabinose, glucose
LBPC2   Xylose, rhamnose, mannose
LBPC4   Glucose
LBPF1   -

2.2. Carotenoids

Carotenoids are known to have preventive effects against chronical diseases [12]. Carotenoid, the reason of red-orange color of Lycium barbarum and the focus of attention as the second essential bioactive component, exists in the dried fruit in approximately 2-4 mg per gram by weight (8, 13). Zeaxanthin dipalmitate comprises the 56% of the total carotenoid amount in the fruit. Lycium barbarum also contains β-cryptoxanthin palmitate, zeaxanthin monopalmitate, and low amounts of free zeaxanthin and β-carotene. High amounts of dipalmitates and the higher bioavailability of esterified zeaxanthin (1143.7 μg/g dried fruit) compared to free carotenoid make this fruit unique among other fruits [13].

2.3. Other Components

Lycium barbarum contains small molecules and various vitamins in its structure, such as p-coumaric acid [8]. Fruits contain 18 types of amino acids, 8 of which are essential amino acids, such as isoleucine and tryptophan. It is also the source of 21 trace minerals including zinc, iron, copper, calcium, selenium, and phosphor, and also thiamin (B1), riboflavin (B2), pyridoxine (B6), vitamin E, and vitamin C [15].

In a study on Lycium barbarum fruit produced in 3 different regions of China, iron, manganese, copper, chrome, lead, and cadmium contents were analyzed, and the samples were detected to contain approximately 110 mg/kg Zn, 67 mg/kgFe, 8.3 mg/kg Cu, 5.94 mg/kgMn, 0.4 mg/kg Cr, <0.1 mg/kg Pb, and <0.01 mg/kg Cd. The supplement rate of 20 g dried Lycium barbarum was estimated for the required daily intake amount for adult females and males according to dietary reference intakes (DRI). It was found that iron, manganese, zinc, and copper are respectively supplied in 7.44%, 6.23%, 27.5%, 18.44%, 32% for women, and 16.25%, 5.26%, 25%, 18.44%, 22.86% for men [16].

3. Health Effects of Lycium barbarum

The fast increase in the development of various diseases brings along an increasing attention to preventive and curative foods. Food analyses as well as clinical and epidemiological studies focus on researching nutritional sources beneficial for organism [17-19].Thanks to its countless various positive effects on health as stated above, Lycium barbarum has recently taken its place among the most researched herbal nutritional sources [20]. Positive health effects of Lycium barbarum are summarized in Fig. 1.

Figure 1. Health Effects of Lycium barbarum.

3.1. Antioxidant Activity

Lycium barbarum displays scavenging activity against free radicals in human body, such as superoxide anions and hydroxyl radicals [21]. The fruit has these properties thanks to the carotenoid pigments, flavonoids, polysaccharide fractions and 2-O-β-D-glucopyranosyl-L, a vitamin C analogue, in its structure [17]. Oxygen Radical Absorption Capacity (ORAC) is a method to examine the antioxidant capacity of nutrition, and in this method, this capacity is evaluated with respect to the inhibition degrees of peroxide radicals. However, these values are independent from the metabolism and absorption events of the organism [22]. ORAC values of some berry fruits are illustrated in Fig. 2.

Figure 2. Oxygen Radical Absorption Capacity (22).

Alternative reagents used in determining the antioxidant capacity are composed of glutathione related enzymes (e.g., glutathione peroxidase (GSH-Px)), superoxide dismutase (SOD), DNA oxidation, and, as an indicator of the changes in prostaglandin levels and lipid peroxidation, malondialdehyde (MDA), and other determinants. In a placebo-controlled, randomized double-blind study, 50 male and female individuals between 55 and 72 were separated into two different groups, and then, for 30 days, one group was given 120 mL Lycium barbarum juice, while the other group was given placebo. A positive correlation was found between the consumption of Lycium barbarum juice and GSH-Px, SOD, and MDA levels [23].

In another study conducted with rats, LBP extract in different amounts was administered to diabetic rats for 30 days (0 mg/kg, 50 mg/kg, 100 mg/kg, 200 mg/kg); hence, a decrease in the plasma insulin levels of diabetic rats and an increase in SOD activity and MDA levels were observed; furthermore, it was highlighted that LBP could be used as an anti-hyperglycemic agent [24]. In studies conducted with rats fed on high-fat diet, the effects of LBP on blood glucose, blood lipids, and oxidative stress were examined; as a result, it was observed that LBP significantly reduced the LDL-C (low density lipoprotein cholesterol), total cholesterol, triacylglycerol, blood glucose, and thiobarbituric acid reactive substance levels, while SOD, GSH-Px, and catalase (CAT) enzyme activities increased [25,26].

3.2. Immunomodulatory and Anticancer Activity

Substances in Lycium barbarum display anti-proliferative and pro-apoptotic activity against cancer. This fruit also has an immune functions stimulating property [17]. It also has a preventive role against possible side effects of chemotherapy and radiotherapy. It has been stated that Lycium barbarum earns these properties with isolated Lycium barbarum polysaccharides (LBP), scopoletin (6-metoxy-7-hydrocumarine), 2-O-β-D-glucopyranosyl-L-ascorbic acid, and countless active components in its structure [27]. It was shown that Lycium barbarum extracts prepared in high doses (≥5 g/L) stimulate p53 protein, and thus, mediate for the apoptosis of hepatocellular carcinoma cells [28]. Another study showed that Lycium barbarum polysaccharides inhibit the proliferation of cervical carcinoma cells. It was reported that in the carcinoma cells to which LBP is applied, the mitochondrial transmembrane potential decreases and the entrance of Ca2+ ions into cells are enabled [29]. In a study conducted by Mao et al., it was found that Lycium barbarum polysaccharides applied to SW480 and Caco-2 cells for 8 days in the amounts ranging between 100–1000 mg/L inhibit the activity of colon cancer cells depending on dose increase. It was reported that the development of cancer cells are prevented in the G0/G1 phase, which is an important result of this study [30].

In another study in which healthy individuals (n=150) were given milk-based Lycium barbarum formulation (530 mg/gLycium barbarum, 290 mg/g milk) and placebo for 3 months, and thus immune reaction against influenza vaccine was analyzed, it was observed that serum immunoglobulin G levels significantly decreased without any observed side effect in the group that received this formulation between 30 and 90 days [31]. In another study conducted with healthy adults (n=60), participants were given Lycium barbarum juice (120 mL) and placebo; as a result, it was reported that lymphocyte, interleukin-2, and immunoglobulin G levels of the group given Lycium barbarum juice increased without any side effect [32]. In another study, rats exposed to ionizing radiation were given different amounts of LBP (50 mg/kg, 100 mg/kg, 200 mg/kg) and when the bone marrow mononuclear cells of these rats, which were killed on the days 1, 7, and 14, were analyzed, it was observed that LBP significantly reduced the percentage of G0/G1 phase, apoptosis, MDA levels, and CD44 and CD49d expressions, while increasing the SOD activity [33]. Anticancer activity displaying Lycium barbarum components and molecular formulae are provided in Table 3.

Table 3. Anticancer Activity Displaying Lycium barbarum Components and Molecular Formulae [28].

Classification Component Molecular Formula
Proteoglycans Lycium barbarum polysaccharides (LBP)  
Phytoalexin Scopoletin C10H8O4
Vitamin C analogue

2-O-β-D-Glucopyranosyl-L-ascorbic acid (AA-2βG)


3.3. Hypoglycemic and Hypolipidemic Effect

While 4% of the world population suffers from diabetes, it has been reported that this rate will reach up to 5.4% by 2025 [34]. Apart from exercise, diet, and medical treatments, antidiabetic herbs have also been a focus of attention recently. It is stated that there are more than 400 plants known to reduce blood glucose level and also 100 polysaccharides that display hypoglycemic activity. L. barbarum is also listed among plants having hypoglycemic and hypolipidemic activity with polysaccharides in its structure [35].

In a study conducted with 40 diabetic rats, rats were fed on a high-fat diet and separated into 5 groups (n=8) (control group, 100 mg/kg LBP administered group, and 50, 100, 200 mg/kg LBP IV administered group). HbA1c, blood glucose, triglyceride, total cholesterol, and LDL-C levels of rats that were treated with LBP (100 mg/kg) and LBP IV (200, 100, 50 mg/kg) extract significantly decreased compared to the diabetic control group. As a result of this study, it was reported that Lycium barbarum and LBP isolated from Lycium barbarum can be used as an antidiabetic agent [36].

In another study, 35 rabbits that had developed hyperlipidemia and hyperglycemia through alloxan injection were given Lycium barbarum juice extract (0.25 g/kg/day), crude LBP (10 mg/kg/day), and LBP X (10 mg/kg/day), while the control group was given only saline solution. It was stated that there was a significant decrease in the blood glucose, serum total cholesterol, and triglyceride levels of the rats which were given LBP-X, a fraction of crude LBP, and isolated polysaccharide, and at the same time there was an increase in the HDL-C (high density lipoprotein cholesterol) levels [37].

In another study conducted with rats, rats (n=50) were separated into two groups as experimental and control. The experimental group was also separated into sub-groups according to the amount of LBP infusion administered (100 mg/kg, 200 mg/kg, and 300 mg/kg) and this group was fed on a high-fat diet. At the end of this 30-day treatment, it was found that there was a decrease in TG, LDL-C, triacylglycerol and glucose levels, but an increase in HDL-C levels of the experimental group depending on dose [38].

In a study conducted with 67 individuals with type 2 diabetes, the experimental group was given 300 mg/day LBP isolated from fruit for 3 months, and, as a result, it was reported that there was a significant decrease in postprandial glucose and TNF-α levels, and an increase in HDL-C levels at the same time [38]. In a study in which the experimental group was consisted of rats fed on a high-fat diet (n=56), rats were given different amounts of LBP (100 mg/kg, 250 mg/kg, 500 mg/kg) while the control group was only given saline. It was stated that LBP inhibited albuminuria, blood urea nitrogen concentration, and IL-2, IL-6, TNF-α, IFN-α, MCP-1, and ICAM-1 levels, while increasing SOD and GSH-Px activity and also inhibiting phosphor-nuclear factor kappa B (NF-κB) expression in renal tissues [39].

3.4. Preventive Effects on Retina Cells

Lycium barbarum extracts have a preventive function in the early phase of retina degeneration. Lycium barbarum, with zeaxanthin and luteolin, which are the carotenoids absorbing the light, contributes to the inhibition of neuron apoptosis, and plays a preventive role for the nerve cells in the retina [17]. In a study examining the effects of Lycium barbarum on the nerve cells in retina, it was found that caspase-2 enzyme activity, responsible for retina apoptosis, of the experimental group, which was given 1 mg/kg Lycium barbarum extract, significantly decreased on day 25 compared to the control group [40].

It was reported that when rats are given Lycium barbarum orally, there is a decrease in intraocular pressure and retina cell loss. It is considered that this effect is due to the light absorption feature of zeaxanthin [8].

3.5. Effects on General Health, Aging, and Weight Loss

Studies in recent years have shown that daily Lycium barbarum juice consumption (GoChi 120 mL=150 g fresh fruit) in the menstrual period improves the general health condition, neurological / psychological condition, and cardiovascular, joint/muscle functions, and gastrointestinal regulation at the end days 14 or 30 without any side effect [41]. It is also pointed out that, with the use of Lycium barbarum, there is an improvement in energy levels, athletic performance, sleep quality, stress, emotional status, and happiness, and a decrease in headache, depression, back pain, concentration impairment, and malaise [41,42].

In another study in which the effect of Lycium barbarum juice in 35 individuals (n= 17 treatment group, n=18 placebo control group) was researched, participants were given GoChi for 14 days and the affected parameters were analyzed on day 15. It was found that athletic performance, sleep quality, and concentration power of the group given GoChi improved. While 70% of the treatment group stated that they could wake up easily, their mental sensitivity and concentration power improved, 50%-60% of the participants stated that they felt healthier and happier, 50% of participants stated that they felt less tired and more energetic on the days they consumed juice [43]. It is accepted that the accumulation of oxidative stress factors accelerates the aging process. Lycium barbarum displays its anti-aging effect by behaving like toxic agent against free radicals [44]. It is also stated that there is a decrease in the AGE serum levels, end products of advanced glycations, and an increase in the improvement of motor and cognitive activities and erythrocyte SOD levels in the rats fed with 100 mg/kg per day Lycium barbarum polysaccharides. It is stated that there is a decrease in the plasma triglyceride levels and an increase in plasma cAMP and SOD levels in humans administered 500 mg Lycium barbarum in total within a 10-day period of diet. Consumption of Lycium barbarum is also reported to have a positive effect on the prevention and treatment of geriatric-related diseases [45].In another study, 29 individuals were separated into experimental and control groups; the experimental group was given 120 mL Lycium barbarum juice for 14 days while the control group was given placebo with the same color and taste with Lycium barbarum juice (a mixture made by mixing 10 mg sucralose, 30 mg artificial fruit flavor, 60 mg citric acid, and 12 mg caramel dye to 30 mL pure water). At the end of the study, it was observed that fruit juice, along with exercise and diet, leads to reduction in waist circumference and thus in central obesity, while increasing resting metabolic rate and energy expenditure [46]. In another study, the experimental group (n=81) was given 120 mL Lycium barbarum juice (GoChi) for 30 days; as a result, it was observed that sleep quality, concentration power, and mental activities of the participants increased, while stress and the sense of weakness decreased [47]. Another study found that, thanks to flavonoids in its structure, Lycium barbarum can be used as an antibacterial agent against Gram (+) and Gram (-) bacteria [48].

4. Lycium barbarum and Allergenicity

Along with its effects on geriatric-related diseases, Lycium barbarum also is a focus of attention due to the side effects occurring with its sole use or with medicament [49].

In a study, skin prick test was administered to two individuals who were observed to show allergic reaction after the consumption of Lycium barbarum juice and their IgE levels were checked. While the first individual was observed to develop anaphylaxis and urticaria on hands, palms, and soles, the second individual was observed to have symptoms of urticaria, itch, and dysphagia on the whole body in general. It was stated that IgE levels increased in both individuals. Lipid transfer proteins are considered to cause the allergic sensitivity against Lycium barbarum [50].

Warfarin, the most frequently prescribed medicine as an anticoagulant in the USA, is known to interact with many plants, supplements, and foods [51]. The INR value (international normalized ratio) of a 71-year old female in whom 1.5 mg/day warfarin treatment was administered for 15 days after the knee surgery was measured as 1.7-2.4 (target 2-3). Then, it was observed that the female, who, thinking that it would purify her body, consumed 60 mL Lycium barbarum juice in total in the mornings and evenings for 4 days, developed rectal bleeding, bruising, and epistaxis at the end of day 4. Lycium barbarum and warfarin interaction has been claimed to be the cause of this incident. Even though its pharmacokinetic mechanism has not been clarified yet, it is pointed out that Lycium barbarum would be dangerous with medicament, and thus, further studies are required on this issue [52]. Recent studies on Lycium barbarum are provided in Table 4.

Table 4. Summary of the Recent Leading Studies on Lycium barbarum.

Reference Scope of the Study Duration of the Study Relationship with
Du et al., 2016 64 rats > 4 weeks Decrease in albuminuria, blood urea nitrogen concentration and IL-2, IL-6, TNF-α, IFN-α, MCP-1 and ICAM-1 levels; increase in SOD and GSH-Px activity and inhibition of NF-κB expression in renal tissues
Zhou et al., 2016 30 rats 14 days Decrease in G0/G1 phase rates, apoptosis, MDA levels and CD44 and CD49d expression; increase in SOD activity in the marrow mononuclear cells of the rats killed on the 1., 7., and 14. days with different amounts of LBP
Cai et al., 2015 67 individuals with Type 2 diabetes 3 months Decrease in postprandial glucose and TNF-α levels; increase in HDL-C levels with LBP consumption isolated from fruit
Zhao et al., 2015 40 diabetic rats > 6 weeks Decrease in HbA1c, blood glucose, trigliserit, total cholesterol and LDL-C levels with LBP and LBP-IV extract treatment
Zhu and Zhang, 2013 Cervical carcinoma cells 2., 4., 6. days Inhibition in the proliferation of cervical carcinoma cells with LBP application
Hsu et al., 2012 81 adults 30 days Increase in sleep quality, concentration power, mental activity and healthy-feeling; decrease in stress and sense of weakness with juice consumption
Ni et al., 2012 40 rats 50 days in total Decrease in the caspase-2 enzyme activity, responsible for retina apoptosis, with L. barbarum extract
Rivera et al., 2012 1 adults <1 week Development of rectal bleeding, bruising and nasal bleeding in an individual who has consumed juice with Warfarin treatment
Vidal et al., 2012 150 healthy individuals 3 months Increase in immune reaction against influenza vaccine with milk based Lycium barbarum formulation
Amagase and Nance, 2011 29 adults 14 days Reduction in waist circumference and central obesity with juice consumption and exercise and diet; increase in resting metabolic rate and energy expenditure
Ballarin et al., 2011 2 adults <24 hours Increase in IgE with fruit consumption
Cui et al., 2011 50 rats 30 days Decrease in serum TG LDL-C, triacylglycerol and glucose levels, increase in HDL-C levels depending on dose with LBP infusion
Mao et al., 2011 SW480 and Caco-2 cells 8 days Decrease in the activity of colon cancer cells and halt of cancer cells in G0/G1 phase with LBP application depending on dose
Wu et al., 2010 Ming et al., 2009 50 rats 2 months Decrease in LDL-C, total cholesterol, triacylglycerol, blood glucose and thiobarbituric acid reactive substance levels; increase in SOD, GSH-Px and CAT activity with LBP application to rats fed on high-fat diet
Amagese, Sun and Borek, 2009 50 adults 30 days Increase in GSH-Px, SOD and MDA levels with 120 mL Lycium barbarum juice
Amagese, Sun and Nance, 2009 60 healthy individuals 30 days Increase in lymphocyte, interleukin-2 and immunoglobulin G levels with Lycium barbarum juice consumption
Amagase and Nance, 2008b 35 adults 14 days Waking up easily, improvement in mental sensitivity, increase in concentration power and healthy, happy and energetic feelings; decrease in tiredness with fruit juice

5. Safe Intake Amount of Lycium barbarum

Considering the studies conducted in humans, it has been stated that 120 mL Lycium barbarum juice contains approximately the same amount of Lycium barbarum with 150 g fresh Lycium barbarum fruit. No toxic effect has been observed with fresh fruit or fruit juice consumption in healthy individuals. However, it is known to cause side effects in individuals with allergic sensitivity and in those who take Warfarin [8]. Although the safe intake amount has not been determined yet, ancient Chinese sources indicate that they consumed 6-15 g/day fruit [53]. Individuals under medical treatment and with sensitivity to foods in the same family with Lycium barbarum such as tomatoes and eggplants should consume this fruit carefully. In 2006, FDA (Food and Drug Administration) banned the indication of products with Lycium barbarum contents as medicament or curative products. Furthermore, Lycium barbarum does not take place in GRAS (Generally Recognized as Safe) list of FDA.

6. Conclusion and Suggestions

Lycium barbarum has a long attitude of usage in nutirition and pharmaceutical in East Asian Countries. It is difficult to deduce a certain conclusion about clinical effects of Lycium barbarum very, which, with its nutritive and curative properties. It is, on the other hand, worth attention that the components isolated from this fruit can be used for the prevention of aging-related conditions, and the treatment of geriatric-related diseases.

Many products with such names as Himalaya Lycium barbarum or Tibet Lycium barbarum are on the shelves of markets all around the world. Commercial products are not limited to juices and beverages only, cookies, chocolates, mueslis, soups, and sauces with Lycium barbarum content have also been produced. Regarding the various products found on the food market, there are no scientific evidences to defend the claims made for products as a magical for well-being. People using anticoagulant and having allergic sensitivity should be careful with Lycium barbarum consumption to potential risk of drug interaciton.

It has been proven that Lycium barbarum has these positive effects on health including antiaging, antioxidant, anticancer, immunomodulating, hypolipidemic, and hypoglisemic thanks to the polysaccharides (LBP), zeaxanthin and other vitamin C analogue components displaying biological activity. More studies are needed to interpret detailed mechanisms of these diverse actions. Properly arranged long term extract studies in animals and humans are demanded in order to reach certain conclusions.


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